Why don't eye drops work for my dry eye?
If drops only help for a few minutes, the problem usually isn't the drop. It's that drops treat the symptom, not the cause. What's actually going on.
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A plain comparison of the artificial tears you can actually buy in Australia (water-based, lipid-based, gels and preservative-free), matched to the type of dry eye you have.
Last reviewed: 20 July 2026
AI-assisted draft, human-edited. Clinical review pending: see our editorial policy.
There's no single best drop. The right one depends on your type of dry eye. For evaporative dry eye (the common kind), a lipid-based drop like NovaTears or Cationorm suits best. For watery-deficient eyes, a preservative-free water-based drop like Hylo-Fresh or Systane works well. If you dose more than four times a day, choose preservative-free.
If you’ve stood in the pharmacy aisle staring at a wall of little boxes that all say “for dry, irritated eyes”, you already know the problem: they can’t all be right for you, and nothing on the shelf tells you which one is. Choosing well isn’t about finding the strongest drop. It’s about matching the drop to what’s actually wrong with your tears.
Below, the categories broken down, what to buy in Australia, and roughly what to expect to pay. One thing up front: the best drop is a support, not a fix. If you’re using drops constantly, read our guide on why eye drops often don’t work alongside this one.
The single most useful thing you can do before buying is work out whether your dryness is mostly evaporative or mostly aqueous-deficient, because they need different drops.
You can have both. If you’re not sure, a proper dry eye assessment will tell you, but the descriptions above are enough to make a sensible first choice.
Because the problem is a failing oil layer, you want a lipid-based drop that adds oil to slow evaporation. In Australia the common options include:
If you’ve only ever tried thin, clear, water-based drops and felt they did nothing, a lipid-based drop is the most likely thing to change your mind, because it addresses the actual mechanism.
Here you’re topping up the watery layer, so a water-based drop is the right tool. Good preservative-free choices in Australia include:
Hyaluronic acid is worth looking for on the label: it holds water on the eye’s surface and tends to last longer than plain saline-style drops.
Thicker formulations, gels and ointments, stay on the eye far longer but blur your vision, so they’re overnight tools rather than daytime ones. They’re especially useful if you wake with dry, stuck-feeling eyes, which points to your lids not fully closing overnight.
If your dryness is worst first thing in the morning, our guide on doing a warm compress properly pairs well with a night-time gel.
For a lot of people, this is the most important decision of all, and it’s independent of the water-versus-lipid question.
Standard multi-use bottles usually contain a preservative to keep them sterile once opened, most often benzalkonium chloride (BAK). Used occasionally, it’s fine for most eyes. Used frequently and over months, the research is fairly consistent that BAK can irritate and damage the surface cells of the eye, which can worsen the dryness you’re treating.
The rule of thumb clinicians use: if you’re using drops more than about four times a day, go preservative-free. Preservative-free drops come as single-use vials or in the valve bottles mentioned above, and you can use them as often as you like. If you only reach for drops now and then, a preserved bottle is perfectly reasonable and cheaper.
Where you shop shapes what you can choose from, and the ranges differ more than people expect.
Pharmacies carry the full range. Chains such as Chemist Warehouse and Priceline, and independent pharmacies, stock the lipid-based drops (NovaTears, Cationorm), the preservative-free valve bottles (Hylo-Fresh, Hylo-Forte), single-use vials, gels and ointments. Larger chains often price sharper and run the bigger vial packs that work out cheaper per dose, while a good independent pharmacist earns their keep by helping you match a drop to your symptoms. If you need anything lipid-based or preservative-free, a pharmacy is where you’ll find it.
Supermarkets carry the basics. Woolworths and Coles typically stock a small shelf of mainstream preserved drops, standard water-based lubricants and redness-relief products. Fine for an occasional-use bottle in the trolley, but the specialist formulations this guide recommends for regular use, lipid-based and preservative-free in particular, mostly aren’t there.
Online pharmacy stores carry the widest ranges and are useful for repeat-buying a drop you already know suits you, especially vial multipacks.
Rough price bands are consistent wherever you shop: basic preserved water-based drops around $8 to $15, preservative-free and hyaluronic-acid options around $15 to $30, and lipid-based drops around $20 to $35. Prices move between retailers and specials, so compare on the formulation you want rather than shopping by brand of store. No prescription is needed for any of them.
If you want a shortcut rather than a full comparison:
People tend to buy a drop, use it twice, feel no dramatic change and move on. That’s too quick to judge. A lubricating drop for daytime dryness should feel at least a little better within minutes of putting it in: that’s the immediate comfort test. But whether it’s the right ongoing drop is better judged over about a week of regular use, dosed properly (not one grudging drop a day, but whenever your eyes feel dry). If a well-matched drop used consistently for a week isn’t holding your eyes comfortable, the issue is more likely the cause underneath than the drop on top.
One practical tip: change one thing at a time. If you switch brand, formulation and dosing all at once and it helps, you won’t know which change did it. Swap deliberately.
Two situations trip people up. If you wear contact lenses, not every drop is safe to use with lenses in. Some are labelled specifically as contact-lens-friendly rehydrating drops, and others should only go in with lenses out. Check the box, and if in doubt, put drops in before your lenses and after taking them out rather than over the top. If your eyes are dry because of your lenses, drops are only a patch: the lens fit or material may be the real problem.
If you wear eye makeup, thicker gels and any oily lipid drops can smudge liner and mascara, so people save those for night and use a thin water-based drop during the day. Makeup along the waterline can also block the very oil glands you’re trying to keep clear, which is worth knowing if your dry eye is evaporative.
Even the perfect drop, perfectly matched, is managing a symptom. If your dry eye is evaporative, and most is, the drops sit on top of a deeper problem: oil glands that aren’t doing their job. Drops keep you comfortable, but they don’t unblock a gland or calm the inflammation underneath.
That’s not a reason to skip them. It’s a reason to see them as one layer of a plan that also includes lid care, warm compresses done properly, and, for many people, an in-clinic assessment to find out what’s actually driving the dryness. If you’ve been buying drop after drop hoping the next one is the answer, the more productive next step is usually getting your tear film and oil glands measured, so you stop guessing.
A gel or ointment. They're thicker than daytime drops, so they stay on the eye for hours while you sleep and protect the surface overnight. The trade-off is blur, which is why they suit bedtime rather than daytime. In Australia you'll find gel drops such as Systane Gel and lubricating eye ointments at most pharmacies.
If you use drops more than about four times a day, yes. The preservative in standard bottles (often benzalkonium chloride) can irritate the eye surface with frequent, long-term use. Preservative-free drops come in single-use vials or valve bottles and can be used as often as needed. If you only use drops occasionally, a preserved drop is usually fine and cheaper.
Most artificial tears sit between about $10 and $30 for a bottle or a box of single-use vials, depending on the brand and formulation. Lipid-based and preservative-free options are generally at the higher end. Prices vary between pharmacies, and larger packs of vials usually work out cheaper per dose.
No. All the drops discussed here are over-the-counter and available without a prescription at Australian pharmacies. Prescription drops are a separate category for specific situations and are decided by a clinician after an assessment, so they're not something to compare or buy off the shelf.
Browse dedicated dry eye clinics across Australia and book a proper assessment.
If drops only help for a few minutes, the problem usually isn't the drop. It's that drops treat the symptom, not the cause. What's actually going on.
Read guideA step-by-step walkthrough of a proper dry eye assessment in Australia: meibography, tear breakup time, osmolarity, the OSDI questionnaire, and what it costs.
Read guideA step-by-step guide to warm compresses that actually work: the right mask, the right temperature, how long to hold it, and the lid massage most people skip.
Read guideThis page is general information, not medical advice. See a qualified clinician to find out what is right for you.